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As previously described (Strbe et al., 2021), intestinal tissue damage was analyzed using a histologic scoring scale adapted from Chui and coworkers (Chui et al., 1970) on a scale of 05 (normal to severe) in three categories (mucosal injury, inflammation, and hyperemia/hemorrhage) for a total score of 015, as described by Lane and coworkers (Lane et al., 1997)

No withdrawals due to adverse effects

These injections need to be kept refrigerated and protected from light, so we always provide clear storage instructions

Examining trial-specific data is beyond the current scope, but we can gain summative insights from meta-analyses of these RCTs